This article presents the design and implementation of a network intervention to foster scientific collaboration at a research university, and describes an experimental framework for rigorous evaluation of the intervention’s impact. Based on social network analysis of publication and grant data, an innovative type of research funding program was developed as a form of alteration of the university’s collaboration network. The intervention consisted in identifying research communities in the network and creating a new collaborative relation between pairs of unconnected researchers in selected communities. The new collaboration was created to maximally increase the overall cohesion of the target research community. In order to evaluate the impact of the program, we designed a randomized experiment with treatment and control communities based on the Rubin Causal Model approach. The paper describes the intervention design, reports findings from the program implementation, and discusses the statistical framework for future evaluation of the intervention.